Publications

h-index: 24
orcid.org/0000-0002-5791-8555

52
PCA, PC-CVA, and Random Forest of GCIB-SIMS Data for the Elucidation of Bacterial Envelope Differences in Antibiotic Resistance Research
Alfred Fransson, Kelly Dimovska Nilsson, Alex Henderson, Anne Farewell and John S. Fletcher
Analytical Chemistry 96 (2024) 14168-14177
51
Weakly supervised anomaly detection coupled with Fourier transform infrared (FT-IR) spectroscopy for the identification of non-normal tissue
Dougal Ferguson, Alex Henderson, Elizabeth F. McInnes and Peter Gardner
Analyst 148 (2023) 3817-3826
50
Infrared micro-spectroscopy coupled with multivariate and machine learning techniques for cancer classification in tissue: a comparison of classification method, performance, and pre-processing technique
Dougal Ferguson, Alex Henderson, Elizabeth F. McInnes, Rob Lind, Jan Wildenhain and Peter Gardner
Analyst 147 (2022) 3709-3722
49
Exploring AdaBoost and Random Forests machine learning approaches for infrared pathology on unbalanced data sets
Jiayi Tang, Alex Henderson and Peter Gardner
Analyst 146 (2021) 5880–5891 [raw data] [processed data and source code] [presentation]
48
Clinical Applications of Infrared and Raman Spectroscopy: State of Play and Future Challenges
Matthew J. Baker, Hugh Byrne, John M. Chalmers, Peter Gardner, Royston Goodacre, Alex Henderson, Sergei Kazarian, Francis L. Martin, Julian Moger, Nick Stone and Josep Sulé-Suso
Analyst 143 (2018) 1735–1757 [Author Accepted Manuscript]
47
Quantum Cascade Laser Spectral Histopathology: Breast Cancer Diagnostics Using High Throughput Chemical Imaging
Michael J. Pilling, Alex Henderson and Peter Gardner
Analytical Chemistry 89 (2017) 7348–7355 [data supporting this publication]
46
Infrared spectral histopathology using haematoxylin and eosin (H&E) stained glass slides: a major step forward towards clinical translation
Michael J. Pilling, Alex Henderson, Jonathan H. Shanks, Michael D. Brown, Noel W. Clarke and Peter Gardner
Analyst 142 (2017) 1258-1268
45
FTIR imaging of the molecular burden around Aβ deposits in an early-stage 3-Tg-APP-PSP1-TAU mouse model of Alzheimer's disease
Artur Dawid Surowka, Michael Pilling, Alex Henderson, Herve Boutin, Lidan Christie, Magdalena Szczerbowska-Boruchowska and Peter Gardner
Analyst 142 (2017) 156-168 [Author Accepted Manuscript]
44
High throughput Quantum Cascade Laser (QCL) spectral histopathology : a practical approach towards clinical translation
Michael J Pilling, Peter Gardner, Alex Henderson, Michael D Brown, Benjamin Bird and Noel William Clarke
Faraday Discuss. 187 (2016) 135-154
43
Evaluation of biomolecular distributions in rat brain tissues by means of ToF-SIMS using a continuous beam of Ar clusters
Shusuke Nakano, Yuta Yokoyama, Satoka Aoyagi, Naoyuki Himi, John S. Fletcher, Nicholas P. Lockyer, Alex Henderson and John C. Vickerman
Biointerphases 11 (2016) 02A307 [Reproduced here under licence]
42
Mass spectrometric imaging of brain tissue by time-of-flight secondary ion mass spectrometry – How do polyatomic primary beams C60+, Ar2000+, water-doped Ar2000+ and (H2O)6000+ compare?
Irma Berrueta Razo, Sadia Sheraz (née Rabbani), Alex Henderson, Nicholas P. Lockyer and John C. Vickerman
Rapid Commun. Mass Spectrom. 29 (2015) 1851–1862
41
Enhanced FTIR benchtop imaging of single biological cells
Caryn Hughes, Alex Henderson, Mustafa Kansiz, Konrad Dorling, Melody Jimenez-Hernandez, Michael D Brown, Noel William Clarke and Peter Gardner
Analyst 140 (2015) 2080–2085
40
Spatiotemporal lipid profiling during early embryo development of Xenopus laevis using dynamic Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) Imaging
Hua Tian, John S. Fletcher, Raphael Thuret, Alex Henderson, Nancy Papalopulu, John C. Vickerman and Nicholas P. Lockyer
Journal of Lipid Research 55 (2014) 1970-1980
39
Comparing C60+ and (H2O)n+ clusters for mouse brain tissue analysis
Irma Berrueta Razo, Sadia Sheraz, Alex Henderson, Nicholas P. Lockyer and John C. Vickerman
Surf. Interface Anal. 46 (2014) 136–139
38
Assessing the challenges of Fourier transform infrared spectroscopic analysis of blood serum
Caryn Hughes, Michael Brown, Graeme Clemens, Alex Henderson, Geraldine Monjardez, Noel W. Clarke, Peter Gardner
Journal of Biophotonics 7 (2014) 180–188
37
Multivariate Analysis of SIMS Spectra
Alex Henderson
in "TOF-SIMS: Materials Analysis by Mass Spectrometry", 2nd edition, Eds. J.C. Vickerman and D. Briggs, SurfaceSpectra, Manchester and IM Publications, Chichester (2013) 449-484
36
Peptide structural analysis using continuous Ar cluster and C60 ion beams
Satoka Aoyagi, John S. Fletcher, Sadia Sheraz (Rabbani), Tomoko Kawashima, Irma Berrueta Razo, Alex Henderson, Nicholas P. Lockyer, John C. Vickerman
Analytical and Bioanalytical Chemistry 405 (2013) 6621-6628
35
The inherent problem of transflection-mode infrared spectroscopic microscopy and the ramifications for biomedical single point and imaging applications
Paul Bassan, Joe Lee, Ashwin Sachdeva, Juliana Pissardini, Konrad M. Dorling, John S. Fletcher, Alex Henderson and Peter Gardner
Analyst 138 (2013) 144-157
34
ToF-SIMS as a tool for metabolic profiling small biomolecules in cancer systems
Helen L. Kotze, Emily G. Armitage, John S. Fletcher, Alex Henderson, Kaye J. Williams, Nicholas P. Lockyer and John C. Vickerman
Surf. Interface Anal. 45 (2013) 277-281
33
SIMS informatics
Alex Henderson, Jimmy D. Moore and John C. Vickerman
Surf. Interface Anal. 45 (2013) 471-474 [Author Accepted Manuscript]
32
Peak picking as a pre-processing technique for imaging time of flight secondary ion mass spectrometry
Jimmy D. Moore, Alex Henderson, John S. Fletcher, Nicholas P. Lockyer and John C. Vickerman
Surf. Interface Anal. 45 (2013) 461-465 [Author Accepted Manuscript]
31
Time-of-flight SIMS as a novel approach to unlocking the hypoxic properties of cancer
Emily G Armitage, Helen L Kotze, John S Fletcher, Alex Henderson, Kaye J Williams, Nicholas P Lockyer and John C Vickerman
Surf. Interface Anal. 45 (2013) 282-285
30
FTIR microscopy of biological cells and tissue: data analysis using resonant Mie scattering (RMieS) EMSC algorithm
Paul Bassan, Ashwin Sachdeva, Achim Kohler, Caryn Hughes, Alex Henderson, Jonathan Boyle, Jonathan H. Shanks, Michael Brown, Noel W. Clarke and Peter Gardner
Analyst 137 (2012) 1370-1377
29
Interactive spatio-spectral analysis of three-dimensional mass-spectral (3DxMS) chemical images.
Stephen E. Reichenbach, Xue Tian, Robert Lindquist, Qingping Tao, Alex Henderson and John C. Vickerman
Surf. Interface Anal. 43 (2011) 529-534
28
Three-dimensional mass spectral imaging of HeLa-M cells - sample preparation, data interpretation and visualisation.
John S. Fletcher, Sadia Rabbani, Alex Henderson, Nicholas P. Lockyer, John C. Vickerman
Rapid Commun. Mass Spectrom. 25 (2011) 925-932
27
Phenotypic profiling of keloid scars using FT-IR microspectroscopy reveals a unique spectral signature
Katherine A. Hollywood, Marlies Maatje, Iqbal T. Shadi, Alex Henderson, Duncan Angus McGrouther, Royston Goodacre and Ardeshir Bayat
Archives of Dermatological Research 302 (2010) 705-715
26
Factors influencing the discrimination and classification of prostate cancer cell lines by FTIR microspectroscopy.
T. J. Harvey, E. Gazi, A. Henderson, R. D. Snook, N. W. Clarke, M. Brown and P. Gardner
Analyst 134 (2009) 1083-1091
25
Classification and Cluster Analysis of Complex Time-of-Flight Secondary Ion Mass Spectrometry for Biological Samples
Stephen E. Reichenbach, Xue Tian, Qingping Tao, and Alex Henderson
International Conference on Bioinformatics, Computational Biology, Genomics and Chemoinformatics (BCBGC-09) (2009) 78
24
Visualization and analysis of large three-dimensional hyperspectral images
Stephen E. Reichenbach, Xue Tian, Robert Lindquist, Qingping Tao, Alex Henderson, and John C. Vickerman
Proceedings of SPIE 7341 (2009) 734108
23
A comparison of PCA and MAF for ToF-SIMS image interpretation.
Alex Henderson, John S. Fletcher, John C. Vickerman
Surf. Interface Anal. 41 (2009) 666-674 [Author Accepted Manuscript]
22
Explanatory multivariate analysis of ToF-SIMS spectra for the discrimination of bacterial isolates.
Seetharaman Vaidyanathan, John S. Fletcher, Roger M. Jarvis, Alex Henderson, Nicholas P. Lockyer, Royston Goodacre and John C. Vickerman
Analyst 134 (2009) 2352-2360
21
Classification of fixed urological cells using Raman tweezers.
Harvey, Tim J.; Hughes, Caryn; Ward, Andrew D.; Faria, Elsa Correia; Henderson, Alex; Clarke, Noel W.; Brown, Mick D.; Snook, Richard D.; Gardner, Peter.
J. Biophotonics 2 (2009) 47-69
20
Efficient encoding and rapid decoding for interactive visualization of large three-dimensional hyperspectral chemical images.
Reichenbach, Stephen E.; Henderson, Alex; Lindquist, Robert; Tao, Qingping.
Rapid Commun. Mass Spectrom. 23 (2009) 1229-1233
19
Uncovering new challenges in bio-analysis with ToF-SIMS.
John S. Fletcher, Alex Henderson, Gregory X. Biddulph, Seetharaman Vaidyanathan, Nicholas P. Lockyer and John C. Vickerman
Applied Surface Science 255 (2008) 1264-1270
18
Exploratory analysis of TOF-SIMS data from biological surfaces.
Seetharaman Vaidyanathan, John S. Fletcher, Alex Henderson, Nicholas P. Lockyer and John C. Vickerman
Applied Surface Science 255 (2008) 1599-1602
17
A New Dynamic in Mass Spectral Imaging of Single Biological Cells.
John S. Fletcher, Sadia Rabbani, Alex Henderson, Paul Blenkinsopp, Steve P. Thompson, Nicholas P. Lockyer, and John C. Vickerman
Analytical Chemistry 80 (2008) 9058-9064
16
Spectral discrimination of live prostate and bladder cancer cell lines using Raman optical tweezers
Tim J. Harvey, Elsa Correia Faria, Alex Henderson, Ehsan Gazi, Andrew D. Ward, Noel W. Clarke, Michael D. Brown, Richard D. Snook and Peter Gardner
Journal of Biomedical Optics 13 (2008) 064004
15
Discrimination of prostate cancer cells by reflection mode FTIR photoacoustic spectroscopy.
Harvey, Tim J.; Henderson, Alex; Gazi, Ehsan; Clarke, Noel W.; Brown, Mick; Faria, Elsa Correia; Snook, Richard D.; Gardner, Peter.
Analyst 132 (2007) 292-295
14
The Static SIMS Library version 4
J.C. Vickerman, D. Briggs and A. Henderson
SurfaceSpectra, Manchester (2006) CDROM
13
Polyethylene terephthalate (PET) bulk film analysis using C60 +, Au3 +, and Au+ primary ion beams.
Conlan, X. A.; Gilmore, I. S.; Henderson, A.; Lockyer, N. P.; Vickerman, J. C.
Applied Surface Science 252 (2006) 6562-6565
12
ToF-SIMS studies of Bacillus using multivariate analysis with possible identification and taxonomic applications.
Thompson, C. E.; Ellis, J.; Fletcher, J. S.; Goodacre, R.; Henderson, A.; Lockyer, N. P.; Vickerman, J. C.
Applied Surface Science 252 (2006) 6719-6722
11
Rapid discrimination of the causal agents of urinary tract infection using ToF-SIMS with chemometric cluster analysis.
Fletcher, John S.; Henderson, Alexander; Jarvis, Roger M.; Lockyer, Nicholas P.; Vickerman, John C.; Goodacre, Royston.
Applied Surface Science 252 (2006) 6869-6874
10
Secondary Ion Mass Spectrometry, SIMS XV. (Proceedings of the Fifteenth International Conference held in UK 12-16 September 2005.) [In: Appl. Surf. Sci., 2006; 252(19)].
Vickerman, John C.; Gilmore, Ian S.; Dowsett, Mark G.; Henderson, Alex; Editors.
Applied Surface Science 252 (2006) 922 pp.
9
Summary of ISO/TC 201 standard: XXII. ISO 22048: 2004 - surface chemical analysis - information format for static secondary ion mass spectrometry.
Gilmore, I. S.; Seah, M. P.; Henderson, A.
Surface and Interface Analysis 36 (2004) 1642-1644
8
ToF-SIMS Studies of Sulfuric Acid Hydrate Films.
Fletcher, John S.; Henderson, Alex; Horn, Andrew B.; Vickerman, John C.
Journal of Physical Chemistry B 108 (2004) 5960-5966
7
Identification of surface molecular hydrates on solid sulfuric acid films.
Couling, Suzanne B.; Nash, Karen L.; Fletcher, John; Henderson, Alex; Vickerman, John C.; Horn, Andrew B.
Journal of the American Chemical Society 125 (2003) 13038-13039
6
The role of surface molecular hydrates in the heterogeneous interaction of NH3 with sulfuric acid monohydrate.
Nash, Karen L.; Sayer, Robert M.; Couling, Suzanne B.; Fletcher, John; Henderson, Alex; Vickerman, John C.; Horn, Andrew B.
Physical Chemistry Chemical Physics 5 (2003) 5101-5107
5
The Static SIMS Library version 3
J.C. Vickerman, D. Briggs and A. Henderson
SurfaceSpectra, Manchester (2002) CDROM
4
NeuroSpectraNet - a self-organising neural network mechanism for interpretation of complex SSIMS spectra.
Sanni, O. D.; Henderson, A.; Briggs, D.; Vickerman, J. C.
Secondary Ion Mass Spectrometry, SIMS XII, Proceedings of the International Conference on Secondary Ion Mass Spectrometry, 12th, Brussels, Belgium, Sept. 5-10, 1999 (2000) 805-808
3
The Static SIMS Library version 2
J.C. Vickerman, D. Briggs and A. Henderson
SurfaceSpectra, Manchester (1999) pp1200 & CDROM
2
The Static SIMS Library
J.C. Vickerman, D. Briggs and A. Henderson
SurfaceSpectra, Manchester (1997) pp1000 & CDROM
1
The effect of corona treatments on the hygral expansion of wool worsted fabrics.
Carr, C. M.; Dodd, K. J.; Connors, M. A.; Henderson, A.; Vickerman, J.
Journal of the Society of Dyers and Colourists 110 (1994) 383-6