Dr Alex Henderson
Manchester Institute of Biotechnology
The University of Manchester
131 Princess Street
Manchester, M1 7DN, UK
Manchester Institute of Biotechnology
The University of Manchester
131 Princess Street
Manchester, M1 7DN, UK
PCA, PC-CVA, and Random Forest of GCIB-SIMS Data for the Elucidation of Bacterial Envelope Differences in Antibiotic Resistance Research
Alfred Fransson, Kelly Dimovska Nilsson, Alex Henderson, Anne Farewell and John S. Fletcher
Analytical Chemistry 96 (2024) 14168–14177 open access
This publication is part of a long-standing collaboration with John Fletcher's group at the University of Gothenburg. Here, Alfred shows that by weighting the spectral intensity of different mass ranges, we get improved statistical and machine learning response, giving insights to antibiotic resistance in bacteria. The paper is published gold open access, so feel free to explore the details.
Honorary Fellow in Open Research
Senior Technical Specialist (Digital Systems Architect)
In 2023 I was awarded a Fellowship from the UoM Office for Open Research to develop file formats and metadata standards for hyperspectral imaging modalities of spectroscopy and spectrometry.
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I sit on the UoM Research Data Management Operations Committee and develop systems for a number of research teams, including the MIB's mass spectrometry facility (MBCCMS).
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I develop open-source multivariate analysis and machine learning methods for hyperspectral imaging, in partnership with the research teams of Prof. Peter Gardner and Prof. Nick Lockyer.
GitHubIn addition to working at the University of Manchester,
I hold a number of external positions
SurfaceSpectra Ltd, founded by Professors John Vickerman and David Briggs, with Dr Alex Henderson, is dedicated to the supply of high quality scientific information products that embrace and support the exploitation of surface analysis and its complex instrumentation.
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The International Society for Clinical Spectroscopy (CLIRSPEC) is a non-profit organisation, founded in 2015. The Society exists to promote the translation of spectroscopy into the clinical environment, for the general benefit of patients, to improve patient diagnosis and prognosis.
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The remit of ISO/TC 201/SC 3 covers Data Management and Treatment in Surface Chemical Analysis. This includes standardization of database design, the transfer of data between instruments, and specifying the properties of algorithms used for surface chemical analysis.
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